Comparative Efficacy of GnRHa Monotherapy vs Combination Therapy for Central Precocious Puberty
GH combination therapy enhances growth outcomes in children with CPP compared to GnRHa alone. Stanozolol, oxandrolone, and estrogen show promise but require further research. Personalized combination regimens and additional long-term RCTs are needed, particularly involving male patients and non-GH adjunctive therapies.
Authors
- Meng‐Che Tsai (ORCID: https://orcid.org/0000-0003-1057-3315)
- Hsien‐Yu Fan (ORCID: https://orcid.org/0000-0001-9995-9497)
- Yang‐Ching Chen (ORCID: https://orcid.org/0000-0002-0682-3716)
- Chia-Hsuan Tsai (ORCID: https://orcid.org/0000-0002-2786-1703)
- Hsin-Yuan Chang
- Jia-Woei Hou
- Chen Yang (ORCID: https://orcid.org/0009-0001-8759-8783)
- Chien‐Ming Lin (ORCID: https://orcid.org/0000-0001-7525-5743)
Institutions
- Fu Jen Catholic University (TW)
- Tri-Service General Hospital (TW)
- Taipei Medical University Hospital (TW)
- Cathay General Hospital (TW)
- Wan Fang Hospital (TW)
- Children's Healthcare of Atlanta (US)
- Taipei Medical University-Shuang Ho Hospital (TW)
- National Cheng Kung University Hospital (TW)
- Taipei Medical University (TW)
- National Defense Medical Center (TW)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1210/clinem/dgaf617
- Primary Topic
- Hypothalamic control of reproductive hormones
- Type
- article
- Field-Weighted Citation Impact
- 0.00