Diagnostic Accuracy of Albumin Levels in Predicting Colistin-Induced Nephrotoxicity in Critically ill Patients in the Intensive Care Unit

The most notorious and feared side effect of colistin therapy is nephrotoxicity, which is reported in the literature, at rates approaching 40%.3The exact mechanism underlying colistin-induced nephrotoxicity remains incompletely understood, but it is believed to involve direct proximal tubular cell damage and oxidative stress, ultimately leading to AKI.Various risk factors have been proposed to predict and prevent AKI during colistin therapy.Among patient-related risk factors, male sex, advanced age, obesity, diabetes mellitus, impaired liver function tests, and hyperbilirubinemia have been identified as contributors to increased susceptibility.Additionally, treatment-related factors such as septic