The Effect of Visfatin Levels on Blood Pressure and Cardiac Risk Factors in Patients with Acromegaly

Introduction:Acromegaly is a hormonal disorder characterized by gradual somatic changes that influence multiple bodily organs and systems.Cardiovascular complications are the primary cause of mortality in individuals with this condition.Visfatin is one of the adipocytokines whose role in obesity and metabolic diseases is controversial.This study aimed to investigate the correlation between visfatin levels and various laboratory and cardiometabolic parameters in patients diagnosed with acromegaly.Methods: The study included 28 patients diagnosed with acromegaly, forming the patient group.A control group of 27 patients, without a history of chronic disease, was also enrolled from the patient population attending our hospital.Echocardiographic findings and 24-hour blood pressure holter results of all participants were recorded.Blood samples were obtained from the control group and the patients.Results: Patients with acromegaly exhibited a higher proportion of females, fasting blood glucose levels, growth factor-1 levels, and left ventricular end-diastolic diameter compared to the control group.Conversely, visfatin levels were found to be lower in acromegaly patients.No correlation was identified between visfatin levels and blood pressure or other biochemical parameters in these patients.However, a positive correlation was observed specifically between left atrium diameter and visfatin levels. Conclusion:Our study revealed that only a limited number of parameters showed a significant association with visfatin levels.Further research with a larger patient cohort is necessary to confirm these findings.