Application of Polysaccharide Hydrogel Loaded Mesenchymal Stem Cell Exosomes in Diabetic Wound Repair Research Progress

The impaired healing of diabetic wounds is a key factor leading to foot ulcers, wound gangrene, and even amputations in patients. Mesenchymal stem cell exosomes offer a novel therapeutic strategy for diabetic wound repair; however, exosomes are easily cleared by the immune system in vivo and have a short retention time in tissues, resulting in suboptimal therapeutic efficacy. Polysaccharide-based hydrogels are ideal delivery carriers for exosomes. This article analyzes the causes of difficult diabetic wound healing, provides a brief overview of the applications of mesenchymal stem cell-derived exosomes and polysaccharide-based hydrogels in diabetic wound healing, and discusses the role of polysaccharide-based hydrogels loaded with exosomes in promoting diabetic wound healing. This work aims to provide a reference for the application of exosome-loaded polysaccharide-based hydrogels in diabetic wound repair.