Hepatoprotective effects of cirsimaritin against CCl <sub>4</sub> -induced oxidative stress, inflammation, and apoptosis in rats
Cirsimaritin protects against CCl<sub>4</sub>-induced hepatotoxicity by enhancing antioxidant defenses, correcting cytokine imbalance, and inhibiting apoptosis, at least partly via activation of Nrf2/HO-1 and suppression of NF-κB signaling. These findings highlight cirsimaritin as a promising natural hepatoprotective candidate.
Authors
- Yousra Bseiso (ORCID: https://orcid.org/0000-0002-4346-5049)
- Abdelrahim M. Alqudah (ORCID: https://orcid.org/0000-0003-3721-8225)
- Alaa A. A. Aljabali (ORCID: https://orcid.org/0000-0002-9519-6338)
- Badriyah Shadid Alotaibi (ORCID: https://orcid.org/0000-0002-4066-5694)
- Muna Oqal (ORCID: https://orcid.org/0000-0002-3766-5781)
- Esam Y. Qnais (ORCID: https://orcid.org/0000-0002-6203-4527)
- Omar Gammoh (ORCID: https://orcid.org/0000-0001-8801-2652)
Institutions
- Princess Nourah bint Abdulrahman University (SA)
- Zarqa University (JO)
- Hashemite University (JO)
- Pharmaceutical Biotechnology (Czechia) (CZ)
- Yarmouk University (JO)
Publication Details
- Journal
- Drug and Chemical Toxicology
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1080/01480545.2025.2579542
- Primary Topic
- Drug-Induced Hepatotoxicity and Protection
- Type
- article
- Field-Weighted Citation Impact
- 0.00