CSIG-36. LEVERAGING GENOMIC ALTERATIONS IN GLIOBLASTOMA MULTIFORME

Abstract In GBM, the most common genomic events include chromosome 7 gain, chromosome 9p loss, or chromosome 10 loss. At least 80% of GBM tumors have one or more of these chromosome alterations. Since these gains and losses involve entire chromosome arms, we predict that more than one gene on each arm functions to promote tumorigenesis. Using a combination of computational studies and chromosome-specific CRISPR screens, we identified a novel oncogene on chromosome 7 and two novel haploinsufficient tumor suppressor genes on chromosomes 9p and 10.