RBM24 regulates phenotypic switching of smooth muscle cell in vascular remodeling by stabilizing JAK2 mRNA
This study demonstrates that RBM24 promotes vascular remodeling by stabilizing JAK2 mRNA and enhancing the JAK2-STAT3-KLF4 signaling axis. Targeting RBM24 and its associated pathways may offer novel therapeutic strategies against vascular remodeling.
Authors
- Wenhao Sun
- Yuxiu Liu (ORCID: https://orcid.org/0000-0003-0462-477X)
- Jing Liu (ORCID: https://orcid.org/0000-0002-3113-4015)
- Shanshan Wang (ORCID: https://orcid.org/0000-0002-1281-2343)
- Xiuqin Xu
- Daqian Sun
- Huawei Zhang (ORCID: https://orcid.org/0009-0002-0265-1176)
Institutions
- Xiamen University (CN)
- Children’s Hospital of Fudan University Xiamen Branch (CN)
- Xiamen Maternal and Child Health Hospital (CN)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1093/cvr/cvaf219
- Primary Topic
- Kruppel-like factors research
- Type
- article
- Field-Weighted Citation Impact
- 0.00