AATF alleviates cerebral ischemia-reperfusion injury by suppressing endoplasmic reticulum stress-induced ferroptosis through upregulating the PI3K/Akt pathway
AATF mitigates CIRI injury by modulating the ER stress-ferroptosis axis, primarily through the activation of the PI3K-Akt signaling pathway. These findings position AATF as a promising therapeutic target for brain ischemia-reperfusion injury.
Authors
- Qinjing Li
- Jiachuan Wu (ORCID: https://orcid.org/0000-0001-8490-2965)
- Bo Lei (ORCID: https://orcid.org/0000-0001-8253-7634)
- Honggang Wu
- Niandong Zheng (ORCID: https://orcid.org/0000-0003-0056-6867)
- Wei Luo (ORCID: https://orcid.org/0000-0003-2826-1723)
- Shu Chen (ORCID: https://orcid.org/0000-0003-3244-299X)
- Li Chen (ORCID: https://orcid.org/0009-0004-5355-0644)
Institutions
- Leshan Normal University (CN)
- People's Hospital of Bishan District (CN)
Publication Details
- Journal
- Neurological Research
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1080/01616412.2025.2564226
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00