PRDM15 inhibits responses of Tissue-Resident memory T cells by activating PVR/TIGIT axis to mediate gastric cancer immunosuppression
This study demonstrated that PRDM15 in GC cells could recruits the histone methyltransferase complex PRMT5/Mep50/WDR5 to promote PVR transcription, thereby activating the PVR/TIGIT axis, which inhibits T<sub>RM</sub> cells activation and mediates immune escape and GC progression.
Authors
- Xinyao Zhang (ORCID: https://orcid.org/0000-0003-4113-8092)
- Jinsen Zheng
- Tiantian Song (ORCID: https://orcid.org/0000-0003-4057-9929)
- Bin Xiong (ORCID: https://orcid.org/0000-0003-3657-8405)
- Hantao Guo
Institutions
- Sun Yat-sen University (CN)
- Wuhan University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Zhongnan Hospital of Wuhan University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1016/j.jare.2025.11.009
- Citations
- 1
- Primary Topic
- Cancer-related gene regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.81