Periaortic lymphatic vessels protect against thoracic aortic dissection through mobilizing immune response
Our findings demonstrated that the TLN and associated periaortic LVs form a functional lymphatic system, which drains the thoracic aorta and plays an inhibitory role in TAD progression, indicating that enhancing lymphatic function may represent a potential therapeutic strategy for treating TAD.
Authors
- Changping Zhou (ORCID: https://orcid.org/0009-0007-0196-8784)
- Huijun Zhao (ORCID: https://orcid.org/0000-0002-3028-0459)
- Yunpeng Sun
- Min Xu (ORCID: https://orcid.org/0000-0001-6475-0394)
- Han Xu (ORCID: https://orcid.org/0000-0002-2548-6866)
- Wei-Chen Lin (ORCID: https://orcid.org/0000-0001-7223-5931)
- Hongjia Zhang (ORCID: https://orcid.org/0000-0002-5737-4084)
- Wenjian Jiang (ORCID: https://orcid.org/0000-0003-3868-6573)
- Fang‐Yang Huang (ORCID: https://orcid.org/0000-0002-3049-2996)
- Yujun Pei (ORCID: https://orcid.org/0000-0003-2243-3803)
- Dan Zhao (ORCID: https://orcid.org/0000-0003-3834-0142)
- Xiangyu Chu (ORCID: https://orcid.org/0000-0002-3320-9359)
- Jincai Luo
- Tao Zhang (ORCID: https://orcid.org/0000-0002-8120-7489)
- Mao Chen (ORCID: https://orcid.org/0000-0002-7352-0563)
- Di Huang (ORCID: https://orcid.org/0000-0002-5611-7158)
- Mingzhao Li (ORCID: https://orcid.org/0009-0003-9216-6680)
- Liang Shi (ORCID: https://orcid.org/0009-0009-6058-4785)
- Yanjiani Xu (ORCID: https://orcid.org/0000-0002-7765-514X)
Institutions
- King University (US)
- Henan University (CN)
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Sichuan University (CN)
- Karolinska Institutet (SE)
- West China Hospital of Sichuan University (CN)
- Jining Traditional Chinese Medicine Hospital (CN)
- Chinese Institute for Brain Research (CN)
- Beijing Anzhen Hospital (CN)
- Beijing Institute of Water (CN)
- Peking University People's Hospital (CN)
- Shenzhen Technology University (CN)
- Beijing Advanced Sciences and Innovation Center (CN)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1093/cvr/cvaf215
- Primary Topic
- Lymphatic System and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00