PATH-11. Juvenile Psammomatoid Ossifying Fibroma: A Literature Review and Case Study

Abstract OBJECTIVE To synthesize existing literature on JPOF and present a detailed case of a 22-year-old woman with maxillary, frontal, and ethmoidal sinus involvement, highlighting diagnostic features, surgical management, and short-term outcomes. METHODS A review of articles on JPOF was conducted, focusing on clinical presentation, radiologic findings, histopathology, and treatment strategies. Concurrently, we analyzed the case of a 22-year-old female who presented with progressive facial swelling and nasal obstruction. Diagnostic work-up included computed tomography (CT) and magnetic resonance imaging (MRI), followed by histopathological confirmation via endoscopic biopsy. The patient underwent endoscopic-assisted excision with intraoperative navigation to ensure complete lesion removal while preserving adjacent structures. RESULTS Imaging revealed a well-demarcated, expansile lesion with internal calcifications. Histology demonstrated psammoma-like bodies and fibroblastic proliferation, confirming JPOF. Surgical excision achieved clear margins without intraoperative complications. At three months postoperatively, the patient remained symptom-free with no radiologic evidence of recurrence. Literature review underscores the importance of early diagnosis, meticulous surgical planning, and the role of advanced imaging in minimizing morbidity. CONCLUSION JPOF demands a high index of suspicion, accurate imaging, and histopathology for diagnosis. Endoscopic-assisted resection with navigation yields favorable short-term outcomes. Given the lesion’s recurrence risk, long-term surveillance and further research into its molecular pathogenesis are essential to optimize management.