Engineering ovarian tissue via biofabrication and <scp>3D</scp> bioprinting: Challenges and emerging perspectives

Abstract The development of bioprosthetic ovaries using advanced biofabrication and 3D bioprinting technologies has achieved significant attention in recent years. This work begins with an analysis of ovarian anatomy and physiology, emphasizing the critical structural and functional components that must be replicated for an effective engineered in vitro model. It further outlines the principles and capabilities of 3D bioprinting, with a focus on the customization of printing modalities and bioinks to closely mimic native ovarian tissue. Given the ovary's dual functions in gametogenesis and endocrine signaling, attention is given to how engineered constructs can be designed to restore hormonal homeostasis through the precise spatial arrangement and biological activity of embedded cells. Finally, the technical challenges and ethical considerations associated with translating bioprinted ovarian tissues into clinical applications are discussed.

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Publication Details

Journal
Bioengineering & Translational Medicine
Published
2025-11-12
DOI
https://doi.org/10.1002/btm2.70088
Primary Topic
3D Printing in Biomedical Research
Type
article
Field-Weighted Citation Impact
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article

Engineering ovarian tissue via biofabrication and 3D bioprinting: Challenges and emerging perspectives

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Bioengineering & Translational Medicine
3D Printing in Biomedical Research
article

Engineering ovarian tissue via biofabrication and 3D bioprinting: Challenges and emerging perspectives

Giulia Artemi, Valentina Palmieri, Antonio Minopoli, Giordano Perini, Marco De Spirito, Massimiliano Papi, Cláudia Marchetti, Camilla Nero, Mario Gennaro Mazza, Alberto Augello, Raffaella Ergasti, Ching Hsu, Valeria Ferrara, Caterina Perfili
article en

Abstract

Abstract The development of bioprosthetic ovaries using advanced biofabrication and 3D bioprinting technologies has achieved significant attention in recent years. This work begins with an analysis of ovarian anatomy and physiology, emphasizing the critical structural and functional components that must be replicated for an effective engineered in vitro model. It further outlines the principles and capabilities of 3D bioprinting, with a focus on the customization of printing modalities and bioinks to closely mimic native ovarian tissue. Given the ovary's dual functions in gametogenesis and endocrine signaling, attention is given to how engineered constructs can be designed to restore hormonal homeostasis through the precise spatial arrangement and biological activity of embedded cells. Finally, the technical challenges and ethical considerations associated with translating bioprinted ovarian tissues into clinical applications are discussed.

Bioengineering & Translational MedicineVol. 11(2)
Università Cattolica del Sacro Cuore (IT), Agostino Gemelli University Polyclinic (IT), Consorzio Roma Ricerche (IT), Institute for Complex Systems (IT), University of Milano-Bicocca (IT)
Openalex Percentile: Top 67%
3D Printing in Biomedical Research
DOIOpen Access PDFOpenAlex
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