Depression in Premanifest Huntington's Disease: Aberrant Effective Connectivity of Striatum and Default Mode Network
These findings establish distinct striatal-network interaction patterns in depression for HDGECs that differ from non-neurological depression. Our findings suggested the posterior DMN-posterior cingulate and hippocampus-as drivers of depression for HDGECs and potential involvement of right DMN in keeping with compensatory patterns broadly in HD. These connectivity patterns could serve as functional biomarkers for depression in HDGECs. © 2025 International Parkinson and Movement Disorder Society.
Authors
- Yifat Glikmann‐Johnston (ORCID: https://orcid.org/0000-0002-6128-7768)
- Nellie Georgiou‐Karistianis (ORCID: https://orcid.org/0000-0003-0718-6760)
- Tamrin Barta (ORCID: https://orcid.org/0009-0003-0880-1558)
- Adeel Razi (ORCID: https://orcid.org/0000-0002-0779-9439)
- Leonardo Novelli (ORCID: https://orcid.org/0000-0002-6081-3367)
- Julie C. Stout (ORCID: https://orcid.org/0000-0001-9637-8590)
- Samantha M. Loi (ORCID: https://orcid.org/0000-0002-4953-4500)
Institutions
- Canadian Institute for Advanced Research (CA)
- The Royal Melbourne Hospital (AU)
- Wellcome Centre for Human Neuroimaging (GB)
- The University of Melbourne (AU)
- Canadian Imperial Bank of Commerce (Canada) (CA)
- University College London (GB)
- Monash University (AU)
Publication Details
- Journal
- Movement Disorders
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1002/mds.70075
- Citations
- 2
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.82