Quantitative Identification of High-Risk Tricuspid Regurgitation by Cardiac Magnetic Resonance
In this large cohort, CMR provided several markers of high risk among patients with TR, with TRF thresholds considered by current guidelines as "moderate" TR already associated with worse long-term prognosis. TRF ≥40% was independently associated with both death and heart failure hospitalization. Moreover, L-ECV emerged as a novel imaging biomarker of systemic venous congestion, identifying right heart failure and adding incremental prognostic value to define high-risk patients with TR.
Authors
- Maurice L. Enriquez-Sarano (ORCID: https://orcid.org/0000-0003-0910-5450)
- Asa Phichaphop (ORCID: https://orcid.org/0000-0002-3195-7863)
- Eustachio Agricola (ORCID: https://orcid.org/0000-0002-4834-2187)
- Miho Fukui (ORCID: https://orcid.org/0000-0002-7235-5551)
- Davide Margonato (ORCID: https://orcid.org/0000-0002-5817-6901)
- Francesco Maisano (ORCID: https://orcid.org/0000-0002-3691-1709)
- Patrizio Lancellotti (ORCID: https://orcid.org/0000-0002-0804-8194)
- Vinayak Bapat (ORCID: https://orcid.org/0000-0002-2579-6434)
- João L. Cavalcante (ORCID: https://orcid.org/0000-0002-3632-2074)
- Fabien Praz (ORCID: https://orcid.org/0000-0001-5416-165X)
- Jörg Hausleiter (ORCID: https://orcid.org/0000-0003-2909-7961)
- Rebecca Tung Hahn (ORCID: https://orcid.org/0000-0003-1342-9191)
- John R. Lesser (ORCID: https://orcid.org/0000-0001-9219-5754)
- Philipp Lurz (ORCID: https://orcid.org/0000-0002-5993-4487)
- Paul Sorajja (ORCID: https://orcid.org/0000-0001-6401-854X)
- Erik B. Schelbert (ORCID: https://orcid.org/0000-0003-0356-4437)
- Tatsuji Nishihara (ORCID: https://orcid.org/0000-0001-7075-9678)
- Cheng Wang (ORCID: https://orcid.org/0000-0001-7236-7424)
- Ellen Cravero (ORCID: https://orcid.org/0009-0000-3035-3825)
Institutions
- Valve (United States) (US)
- Abbott Northwestern Hospital (US)
- NewYork–Presbyterian Hospital (US)
- Vita-Salute San Raffaele University (IT)
- University of Liège (BE)
- Johannes Gutenberg University Mainz (DE)
- Columbia University Irving Medical Center (US)
- University Hospital of Bern (CH)
- LMU Klinikum (DE)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- German Centre for Cardiovascular Research (DE)
- Minneapolis Heart Institute Foundation (US)
- Centre Hospitalier Universitaire de Liège (BE)
- Cardiovascular Research Foundation (US)
Publication Details
- Journal
- Circulation
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1161/circulationaha.125.074862
- Citations
- 4
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.55