Estimating the risk of cardiovascular outcomes and all‐cause mortality in individuals with type 2 diabetes: Validation of the <scp>UKPDS</scp> outcomes model using <scp>TECOS</scp> and <scp>EXSCEL</scp> data
UKPDS-OM2 accurately simulated relative risks between randomized groups in both trials. The proportion of participants with the primary outcome was accurately estimated in both TECOS arms but underestimated by around one-third in both EXSCEL arms.
Authors
- Rury R. Holman (ORCID: https://orcid.org/0000-0002-1256-874X)
- Amanda Adler (ORCID: https://orcid.org/0000-0002-2797-3385)
- Philip Clarke (ORCID: https://orcid.org/0000-0002-7555-5348)
- Ruth L. Coleman (ORCID: https://orcid.org/0000-0002-5194-8550)
- Darren K. McGuire
Institutions
- Parkland Health & Hospital System (US)
- The University of Melbourne (AU)
- University of Oxford (GB)
- Oxford Centre for Diabetes, Endocrinology and Metabolism (GB)
Publication Details
- Journal
- Diabetes Obesity and Metabolism
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1111/dom.70280
- Primary Topic
- Health Systems, Economic Evaluations, Quality of Life
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute for Health and Care Research
- Duke Clinical Research Institute