Integrative analysis of RNA binding proteins identifies DDX55 as a novel regulator of 3’UTR isoform diversity
Our findings identify DDX55 as a new regulator of APA, particularly at PAS that contain features of RNA secondary structure. Our data also suggest additional previously unrecognized regulators of 3'UTR processing and differential stability.
Authors
- Matthew R. Gazzara (ORCID: https://orcid.org/0000-0001-7710-4551)
- Michael J. Mallory
- Yoseph Barash (ORCID: https://orcid.org/0000-0003-3005-5048)
- Kristen W. Lynch (ORCID: https://orcid.org/0000-0002-0120-8079)
- Timothy Cater
Institutions
- University of Pennsylvania (US)
- Philadelphia University (US)
Publication Details
- Journal
- Genome biology
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1186/s13059-025-03852-8
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation