Immunogenicity of a 20-Valent Pneumococcal Conjugate Vaccine Versus a 13-Valent Vaccine in Infants: A Systematic Review and Meta-Analysis
This meta-analysis offers an overview of the evidence on the comparative immunogenicity of PCV20 and PCV13. Although some outcomes indicate that PCV20 elicits lower immune responses for the 13 serotypes shared with PCV13, it provides immunity against seven additional serotypes associated with IPD. Further studies are warranted to strengthen the evidence base, and continuous IPD surveillance remains essential to monitor shifts in serotype prevalence, assess the impact of current and future vaccines, and guide vaccine policy recommendations.
Authors
- Valeria Reynolds-Cortez (ORCID: https://orcid.org/0000-0001-6140-0073)
- Sergio Núñez de Arenas‐Arroyo (ORCID: https://orcid.org/0000-0001-7774-8437)
- Vicente Martínez‐Vizcaíno (ORCID: https://orcid.org/0000-0001-6121-7893)
- Valentina Díaz‐Goñi (ORCID: https://orcid.org/0000-0002-1724-1893)
- Е. Н. Игнатьева
- Elisa-Janeth Velasco-Lucio
- María-Dolores Pacheco-Haro (ORCID: https://orcid.org/0009-0003-5378-3248)
- Carol-Ingrid Castellares-González (ORCID: https://orcid.org/0009-0007-7662-9445)
- Adriana Simeón-Prieto
Institutions
- ProMedica Toledo Hospital (US)
- Universidad Autónoma de Chile (CL)
- Hospital Virgen de la Luz (ES)
- Hospital Universitario 12 De Octubre (ES)
- Complejo Hospitalario Universitario de Toledo (ES)
- University of Castilla-La Mancha (ES)
Publication Details
- Journal
- Vaccines
- Published
- 2025-11-12
- DOI
- https://doi.org/10.3390/vaccines13111156
- Primary Topic
- Pneumonia and Respiratory Infections
- Type
- article
- Field-Weighted Citation Impact
- 0.00