Exercise-Induced Out-Of-Proportion Increase in Afterload and Impaired Right Ventricular Contractile Reserve in HFpEF
Resting RV afterload elevation in HFpEF results in a compensatory increase in contractility. Out-of-proportion increase of afterload paralleled by inadequate increase in contractility results in failure to increase the cardiac index in HFpEF, potentially associated with exertional functional failure.
Authors
- Gerd Hasenfuß (ORCID: https://orcid.org/0000-0002-5942-361X)
- Shelby Kutty (ORCID: https://orcid.org/0000-0001-9428-0979)
- Johannes T. Kowallick (ORCID: https://orcid.org/0000-0002-3580-619X)
- Sören J. Backhaus (ORCID: https://orcid.org/0000-0002-2683-6418)
- Andreas Rolf (ORCID: https://orcid.org/0000-0002-8771-297X)
- Samuel Tobias Sossalla (ORCID: https://orcid.org/0000-0001-8034-2673)
- Andreas Schuster (ORCID: https://orcid.org/0000-0003-1508-1125)
- Alexander Schulz (ORCID: https://orcid.org/0000-0001-6796-3598)
- Torben Lange
- Steffen Kriechbaum
- Julia Treiber
- Jan Sebastian Wolter
Institutions
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- Justus-Liebig-Universität Gießen (DE)
- Asklepios Fachklinikum Tiefenbrunn (DE)
- Global Climate Forum (DE)
- German Centre for Cardiovascular Research (DE)
- Kerckhoff Klinik (DE)
- Johns Hopkins Hospital (US)
- University of Göttingen (DE)
Publication Details
- Journal
- ESC Heart Failure
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1002/ehf2.70007
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsches Zentrum für Herz-Kreislaufforschung