The real-world safety of lacosamide and perampanel in children: a disproportionality analysis of the FDA Adverse Event Reporting System
Our study identified potential new AE signals for lacosamide and perampanel. The findings warned the need for cautious therapeutic decisions during pregnancy and emphasized the importance of rational use of drugs and correct medication education. This postmarketing study provided reference data for the clinical monitoring and treatment of lacosamide and perampanel in children. Our study merely proved the statistical correlations; further research is needed to clarify the causal relationship between the drug and the AEs.
Authors
- Yani Tan (ORCID: https://orcid.org/0000-0002-9476-6124)
- Cuilin Li (ORCID: https://orcid.org/0000-0002-9480-1532)
- Yi Qin (ORCID: https://orcid.org/0000-0003-4351-2463)
- Xin Liu (ORCID: https://orcid.org/0009-0009-5595-3195)
- Yuping Yang (ORCID: https://orcid.org/0000-0002-2226-7676)
- Lian Zheng (ORCID: https://orcid.org/0000-0002-0448-1679)
- Long Wei (ORCID: https://orcid.org/0000-0002-7138-6532)
- Li Huang (ORCID: https://orcid.org/0009-0007-2957-9457)
Institutions
- Central South University (CN)
- Zhuzhou Central Hospital (CN)
Publication Details
- Journal
- Therapeutic Advances in Drug Safety
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1177/20420986251389805
- Citations
- 1
- Primary Topic
- Advanced Causal Inference Techniques
- Type
- article
- Field-Weighted Citation Impact
- 2.63