Copper-catalyzed stereo- and regio-selective decarbonylative alkylation and sequential amination of alkynes with aldehydes and amides
A chelate-assisted copper-catalyzed 1,2-alkylamidation of alkynes with aldehydes and amides have been proposed. The generation of high-capacity alkylated enamides exhibits stubborn anti -stereoselectivity and β-regioselectivity.
Authors
- Daoshan Yang (ORCID: https://orcid.org/0000-0002-3047-5416)
- Jianjing Yang (ORCID: https://orcid.org/0000-0001-9416-1195)
- Kelu Yan (ORCID: https://orcid.org/0000-0002-1551-267X)
- Jiangwei Wen (ORCID: https://orcid.org/0000-0002-4431-9158)
- Bingxin Zhou (ORCID: https://orcid.org/0000-0002-8270-6976)
- Xiaoyu Wang (ORCID: https://orcid.org/0000-0002-8641-2430)
- Yuanyuan Zhang (ORCID: https://orcid.org/0000-0003-4487-2380)
Institutions
- Qingdao University of Science and Technology (CN)
- Nanjing Forestry University (CN)
- Qufu Normal University (CN)
Publication Details
- Journal
- Organic Chemistry Frontiers
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1039/d5qo01356a
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00