Higher Amyloid and Tau Burden Is Associated With Faster Decline on a Digital Cognitive Test
Longitudinal declines in DCTclock performance, especially in Information Processing involving speed and executive function, were linked to early Aβ and tau burden in preclinical AD. These findings highlight the potential of digital cognitive assessment tools for tracking disease progression and assessing therapeutic efficacy in clinical trials.
Authors
- Roos J. Jutten (ORCID: https://orcid.org/0000-0002-3712-4790)
- Randall Davis
- Dana L. Penney (ORCID: https://orcid.org/0000-0003-3105-6974)
- Brian C. Healy (ORCID: https://orcid.org/0000-0001-5272-2425)
- G. Montenegro
- Jessie Fanglu Fu (ORCID: https://orcid.org/0000-0002-4970-7811)
- Talia L. Robinson (ORCID: https://orcid.org/0000-0002-5655-8324)
- Kathryn V. Papp (ORCID: https://orcid.org/0000-0003-1687-4370)
- Dorene M. Rentz
- Julie C. Price
- J. C. Thompson (ORCID: https://orcid.org/0000-0002-7512-7570)
- Emma G. Thibault (ORCID: https://orcid.org/0000-0002-7873-742X)
- Michael J Properzi (ORCID: https://orcid.org/0000-0001-7855-2372)
- Marina Álvarez Alonso
- Keith A. Johnson
- Reisa A. Sperling
- Adela Francis Malave
Institutions
- Brigham and Women's Hospital (US)
- Lahey Hospital and Medical Center (US)
- Harvard University (US)
- Massachusetts General Hospital (US)
- Lahey Medical Center (US)
- Massachusetts Institute of Technology (US)
Publication Details
- Journal
- Annals of Clinical and Translational Neurology
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1002/acn3.70233
- Citations
- 2
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- National Institutes of Health