Programmed death-ligand 1 upregulation is associated with poor prognosis in patients with epithelial ovarian cancer
PD-L1 upregulation (CPS ≥10) is associated with PR, disease recurrence, and poor prognosis in EOC. Endometrioid and clear cell histologic subtypes demonstrated higher baseline PD-L1 expression in our cohort. Cisplatin-induced PD-L1 upregulation represents a tumor-intrinsic response, particularly in PR tumor cells, highlighting PD-L1 as a histology-specific marker of poor prognosis and a potential therapeutic target in platinum-resistant EOC.
Authors
- Chenhao Lin (ORCID: https://orcid.org/0000-0001-5102-801X)
- Chia‐Hao Liu (ORCID: https://orcid.org/0000-0001-8233-5493)
- Szu-Ting Yang
- Kuo‐Chang Wen (ORCID: https://orcid.org/0000-0001-6967-8037)
- Peng‐Hui Wang (ORCID: https://orcid.org/0000-0002-6048-8541)
- Wei‐Ting Chao (ORCID: https://orcid.org/0000-0003-4122-2198)
Institutions
- National Yang Ming Chiao Tung University (TW)
- Taipei Veterans General Hospital (TW)
- Taipei Medical University-Shuang Ho Hospital (TW)
- Taipei Medical University (TW)
Publication Details
- Journal
- Journal of the Chinese Medical Association
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1097/jcma.0000000000001317
- Citations
- 8
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 8.36