Regioselective <scp>C3</scp> ‐Nitration of Pyrazolo[1,5‐ <i>a</i> ]Pyrimidines With Fe( <scp> NO <sub>3</sub> </scp> ) <sub>3</sub> / <scp>TFA</scp> as a Nitrating Agent
ABSTRACT Nitro‐functionalized pyrazolo[1,5‐ a ]pyrimidines are valuable in materials science and energetics, but traditional methods typically require a mixture of sulfuric and nitric acids. This work presents a mild, iron‐complex‐mediated strategy for efficient C3‐selective nitration of pyrazolo[1,5‐ a ]pyrimidin‐7‐amines, providing direct access to these important scaffolds. The utility of this versatile method is highlighted by its successful application in late‐stage modification, gram‐scale synthesis, and further product diversification.
Authors
- Ting Pang
- Li Chen (ORCID: https://orcid.org/0000-0002-1610-9655)
- Ruili Guo (ORCID: https://orcid.org/0000-0001-6572-4868)
- Jing He (ORCID: https://orcid.org/0000-0002-1954-2892)
- Ping Liu (ORCID: https://orcid.org/0000-0002-3689-8364)
- Liwen Liu (ORCID: https://orcid.org/0000-0001-9838-5727)
- Huawei Li (ORCID: https://orcid.org/0000-0001-7673-0884)
Institutions
- Shihezi University (CN)
Publication Details
- Journal
- Journal of Heterocyclic Chemistry
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1002/jhet.70134
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00