Lovastatin‐Loaded Nanoparticles in a Thermosensitive Chitosan Hydrogel as a Sustained Release System for Treating Intervertebral Disc Degeneration: In Vitro Cell Culture Study and In Vivo Evaluation Using a Needle‐Puncture Induced Degeneration Model
LVS-NPs demonstrated sustained release of lovastatin and extended stimulatory effects on human nucleus pulposus cells in vitro. However, further research is needed to optimize the hydrogel volume and its ratio to intradiscal space and increase lovastatin concentration within LVS-NPs to achieve optimal therapeutic outcomes while minimizing mechanical compression to surrounding tissues.
Authors
- Ming‐Hsiao Hu (ORCID: https://orcid.org/0000-0001-8920-2052)
- Chuan‐Ching Huang (ORCID: https://orcid.org/0000-0002-8184-9860)
- Yuan‐Hui Sun
- Jaw‐Lin Wang (ORCID: https://orcid.org/0000-0002-5734-9276)
- Kai‐Chiang Yang (ORCID: https://orcid.org/0000-0002-0979-4463)
- Shuhua Yang (ORCID: https://orcid.org/0000-0002-9879-0164)
- Chih‐Wei Chen (ORCID: https://orcid.org/0000-0002-9309-5824)
- Yung‐Hsin Cheng (ORCID: https://orcid.org/0000-0003-4630-6999)
Institutions
- National Taiwan University of Science and Technology (TW)
- National Taiwan University (TW)
- National Taiwan University Hospital (TW)
- Taipei Medical University (TW)
- National Taipei University (TW)
Publication Details
- Journal
- JOR Spine
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1002/jsp2.70135
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Taiwan University Hospital
- National Taiwan University
- National Science and Technology Council