Multi level effects of Sanghuang Tongxie Formula on type 2 diabetes rats: a comprehensive analysis from intestinal bacteria to metabolome and transcriptome
These results suggest that SHTX treatment may improve metabolic homeostasis in T2DM by modulating gut microbiota and several key metabolic pathways, particularly glycerophospholipid metabolism. However, the study has several limitations, including the reliance on animal models and the incomplete elucidation of the underlying mechanisms. Further studies are needed to confirm these findings and explore the molecular mechanisms of SHTX therapy. Additionally, clinical trials are necessary to assess the therapeutic potential and efficacy of SHTX in human T2DM patients.
Authors
- Chenxi Wu (ORCID: https://orcid.org/0000-0003-2712-4823)
- Chunyu Tian (ORCID: https://orcid.org/0000-0001-6234-9388)
- Xiujuan Gao (ORCID: https://orcid.org/0000-0001-8202-4206)
- Biwei Zhang
- Xiaojin La
- Jian Li (ORCID: https://orcid.org/0000-0003-2094-5610)
- Jiaxuan Liu (ORCID: https://orcid.org/0000-0002-7937-320X)
- Xiumei Cheng
- Sufen Bai
- Qianru Fu
Institutions
- North China University of Science and Technology (CN)
- Hebei University of Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-11-11
- DOI
- https://doi.org/10.3389/fendo.2025.1562105
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00