Characterisation of a touchscreen-based task for assessing cognitive judgement bias in mice: a new translational tool for affective state disorder drug screening
This study underscores the capacity of mice to respond to visually ambiguous stimuli in an ambiguity-dependent manner, a phenomenon observed across various species, including humans. Furthermore, it establishes and validates an operant behavioural task to assess CJB in mice delivered using the touchscreen platform, which has significant cross-species translational potential.
Authors
- Laura López‐Cruz (ORCID: https://orcid.org/0000-0003-4735-6445)
- Lisa M. Saksida (ORCID: https://orcid.org/0000-0002-8416-8171)
- Timothy J. Bussey (ORCID: https://orcid.org/0000-0001-7518-4041)
- Benjamin U. Phillips (ORCID: https://orcid.org/0000-0002-3680-8197)
- Christopher J. Heath (ORCID: https://orcid.org/0000-0003-3485-7128)
Institutions
- Western University (CA)
- The Open University (GB)
- Wellcome/MRC Cambridge Stem Cell Institute (GB)
- University of Cambridge (GB)
- Wellcome Trust (GB)
Publication Details
- Journal
- Psychopharmacology
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1007/s00213-025-06909-5
- Primary Topic
- Memory and Neural Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00