Case Report: Progressive interstitial lung disease secondary to Sjögren’s disease in a patient with inclusion body myositis complicated by dysphagia—a multidisciplinary approach and therapeutic challenges

We present the case of a 78-year-old man with a complex overlap of inclusion body myositis (IBM) and Sjögren's disease (SjD), complicated by interstitial lung disease (ILD) and esophageal dysfunction. The patient's neuromuscular decline was managed with periodic intravenous immunoglobulins (IVIG), while his progressive ILD required a combined immunosuppressive and antifibrotic regimen, including prednisone. This case underscores the diagnostic and therapeutic challenges in managing autoimmune overlap syndromes, particularly the rare coexistence of IBM and SjD-related ILD. We highlight the rationale behind the treatment strategy and the importance of a tailored, multidisciplinary approach in addressing both muscular and pulmonary manifestations.

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Publication Details

Journal
Frontiers in Medicine
Published
2025-11-11
DOI
https://doi.org/10.3389/fmed.2025.1683606
Primary Topic
Inflammatory Myopathies and Dermatomyositis
Type
article
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article

Case Report: Progressive interstitial lung disease secondary to Sjögren’s disease in a patient with inclusion body myositis complicated by dysphagia—a multidisciplinary approach and therapeutic challenges

Emanuele Cocchiara, Andreina Manfredi, Ilaria Chiapparoli, Gianluigi Bajocchi et al.
Frontiers in Medicine
Inflammatory Myopathies and Dermatomyositis
article

Case Report: Progressive interstitial lung disease secondary to Sjögren’s disease in a patient with inclusion body myositis complicated by dysphagia—a multidisciplinary approach and therapeutic challenges

Emanuele Cocchiara, Andreina Manfredi, Ilaria Chiapparoli, Gianluigi Bajocchi, Francesca Cozzini, Carlo Salvarani, Francesco De Falco
article en

Abstract

We present the case of a 78-year-old man with a complex overlap of inclusion body myositis (IBM) and Sjögren's disease (SjD), complicated by interstitial lung disease (ILD) and esophageal dysfunction. The patient's neuromuscular decline was managed with periodic intravenous immunoglobulins (IVIG), while his progressive ILD required a combined immunosuppressive and antifibrotic regimen, including prednisone. This case underscores the diagnostic and therapeutic challenges in managing autoimmune overlap syndromes, particularly the rare coexistence of IBM and SjD-related ILD. We highlight the rationale behind the treatment strategy and the importance of a tailored, multidisciplinary approach in addressing both muscular and pulmonary manifestations.

Frontiers in MedicineVol. 12
University of Modena and Reggio Emilia (IT), Santa Maria Nuova Hospital (IT), Santa Maria Nuova Hospital (IT), Ospedale Santa Maria (IT)
Openalex Percentile: Top 55%
Inflammatory Myopathies and Dermatomyositis
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Case Report: Progressive interstitial lung disease secondary to Sjögren’s disease in a patient with inclusion body myositis complicated by dysphagia—a multidisciplinary approach and therapeutic challenges — Emanuele Cocchiara, Andreina Manfredi, et al. · Frontiers in Medicine (2025) | TGRS Research Map | TGRS