Influence of heparin-based anticoagulants on antibiotic therapy
These findings support our hypothesis that specific heparin-based anticoagulants interfere with the activity of blood-derived AMCs and positively charged antibiotics, reducing their efficacy <i>in vitro</i>. Our research aims to provide a foundation for future studies focused on optimizing anticoagulant use in clinical settings, ultimately improving patient outcomes in the ongoing fight against multidrug-resistant bacteria.
Authors
- Claudia Kolm
- Alexander K. T. Kirschner (ORCID: https://orcid.org/0000-0002-9797-3073)
- Jens Hartmann (ORCID: https://orcid.org/0000-0002-7343-1851)
- Andreas H. Farnleitner (ORCID: https://orcid.org/0000-0002-0542-5425)
- Viktoria Weber (ORCID: https://orcid.org/0000-0002-3963-9077)
- Claudia Schildböck (ORCID: https://orcid.org/0000-0002-4115-479X)
- Stephan Harm (ORCID: https://orcid.org/0000-0003-1944-9898)
- Denisa Cont (ORCID: https://orcid.org/0009-0000-2936-8317)
Institutions
- Universität für Weiterbildung Krems (AT)
- TU Wien (AT)
- Research Institute of Molecular Pathology (AT)
- Karl Landsteiner University of Health Sciences (AT)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-11
- DOI
- https://doi.org/10.3389/fimmu.2025.1708169
- Primary Topic
- Venous Thromboembolism Diagnosis and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00