Mitogen-activated protein kinase pathway and four genes involved in the development of benign prostatic hyperplasia: in vivo and vitro validation
The aberrant overexpression of QPCT, ARHGEF37, FLNC, and LGALS7, along with dysregulation of the MAPK signaling pathway, may contribute to BPH pathogenesis. These findings provide new insights into the molecular mechanisms of BPH and may inform the development of diagnostic markers or therapeutic targets.
Authors
- Jia‐Min Gu (ORCID: https://orcid.org/0009-0007-7557-0445)
- Xian‐Tao Zeng (ORCID: https://orcid.org/0000-0003-1262-725X)
- Shuang-Ying Wang
- Cheng Fang (ORCID: https://orcid.org/0000-0002-8626-9451)
- Lan Wu (ORCID: https://orcid.org/0000-0001-8286-1063)
- Cong Zhu
- Xing‐Pei Guo
- Tong Deng (ORCID: https://orcid.org/0000-0001-5871-1348)
- Luyao Li (ORCID: https://orcid.org/0000-0003-1397-5045)
Institutions
- Henan University (CN)
- Wuhan University (CN)
- Zhongnan Hospital of Wuhan University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-11
- DOI
- https://doi.org/10.3389/fimmu.2025.1606607
- Primary Topic
- Urinary Bladder and Prostate Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundamental Research Funds for the Central Universities