Expression of dementia biomarkers in Appalachian and non-Appalachian ELVO patients during thrombectomy
There was a notable difference in the levels of certain ADRD biomarkers between stroke patients and control patients. Specifically, in Appalachian populations, stroke patients showed significant differences in multiple ADRD biomarkers (AB40, AB42, and GFAP) compared to controls, a pattern not seen in non-Appalachian stroke patients, where only GFAP levels increased. This difference in ADRD biomarkers observed in Appalachian stroke patients could be attributed to a combination of socioeconomic and environmental factors unique to the Appalachian region.
Authors
- Keith R. Pennypacker (ORCID: https://orcid.org/0000-0002-4618-0903)
- Justin F. Fraser (ORCID: https://orcid.org/0000-0002-5980-3989)
- Hunter S. Hazelwood
- Will Cranford
- Mais Al‐Kawaz (ORCID: https://orcid.org/0000-0002-0978-8012)
- David Dornbos (ORCID: https://orcid.org/0000-0002-0039-0016)
- Jacqueline A. Frank (ORCID: https://orcid.org/0000-0002-3216-518X)
- Christopher J. McLouth (ORCID: https://orcid.org/0000-0002-5434-9748)
- Jordan P. Harp (ORCID: https://orcid.org/0000-0003-2089-0883)
- N Millson
- Shivani Pahwa (ORCID: https://orcid.org/0009-0004-7352-5913)
- Neha Anil
- Elise Dahlke
Institutions
- University of Kentucky (US)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2025-11-11
- DOI
- https://doi.org/10.3389/fnins.2025.1672803
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00