Investigation of the Immune System Effects of Desloratadine on Lipopolysaccharide‐Stimulated Mammalian Macrophage Cells
DES selectively modulates macrophage responses, strongly inhibiting TNF-α and IL-12p40 while enhancing GM-CSF, reflecting a dual anti- and pro-inflammatory profile. These findings support further investigation of DES in neuroinflammatory and immune-mediated conditions.
Authors
- Furkan Ayaz (ORCID: https://orcid.org/0000-0003-0271-0594)
- Esra Aydemir (ORCID: https://orcid.org/0000-0002-6965-2838)
- Özdil Başkan
- Batuhan Yurtseven (ORCID: https://orcid.org/0009-0003-5047-3340)
Institutions
- Biruni University (TR)
- Istinye University (TR)
Publication Details
- Journal
- Fundamental and Clinical Pharmacology
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1111/fcp.70056
- Citations
- 2
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.68