Correction to: Gene expression kinetics in Sepsis After Cardiac Surgery (SACS): a multicentric prospective observational study

The original publication of this article contained 2 errors: Several bibliographic references in the abstract were included The data tabulation in table 1 Several bibliographic references in the abstract were included The data tabulation in table 1 The incorrect and correct information is shown in this correction article. The original article has been updated. (Table presented.) Incorrect Abstract Correct abstract Surviving Sepsis Campaign (SSC) defined Sepsis as “life-threatening organ dysfunction caused by a dysregulated host response to infection” (De Backer D et al, Crit Care Med, n.d.). Sepsis remains one of the leading causes of morbidity and mortality (17–65% (De Oliveira DC, Arq Bras Cardiol Sociedade Brasileira de Cardiologia - SBC 94:352–6, 2010)) worldwide and it still remains a challenge to be defined and for which an appropriate treatment is desired (Chiu and Legrand, Curr Opin Anaesthesiol 34:71–6, 2021). Different studies have been conducted on genes coding for inflammatory cytokines whose could predispose to the development of sepsis [e.g., IL-10 PD1 and WT1] (Gupta DL et al, Infectious Process Sepsis, 202). This multicentric observational prospective study aims to evaluate blinding the genetic expression kinetics of different molecules involved in the inflammatory process, IL10, PD1 and WT1, to search for a possible molecular predictive marker of sepsis. Nine University teaching Hospitals in Italy take part in this study in collaboration with the Department of Applied Science (DISBA) of the University of Basilicata. One hundred sixty-two patients, under elective cardiac and on pump surgery were enrolled in the study. From each patient 4 blood samples were collected during and at the end of the surgery, following the study design. We observed, 30 min after the start of the surgery, lower gene expression levels of IL10 and PD1 in septic patients compared to non-septic (p < 0.05), but considering all the timepoint there are differences in gene expression modulation between the groups. These results confirmed the dysregulated immune response in septic patients compared to non-septic, highlight how a measurement of the gene expression could help to optimize procedures and pay attention to more susceptible patients. Surviving Sepsis Campaign (SSC) defined Sepsis as “life-threatening organ dysfunction caused by a dysregulated host response to infection”. Sepsis remains one of the leading causes of morbidity and mortality (17–65 %) worldwide and it still remains a challenge to be defined and for which an appropriate treatment is desired. Different studies have been conducted on genes coding for inflammatory cytokines whose could predispose to the development of sepsis [e.g., IL-10 PD1 and WT1]. This multicentric observational prospective study aims to evaluate blinding the genetic expression kinetics of different molecules involved in the inflammatory process, IL10, PD1 and WT1, to search for a possible molecular predictive marker of sepsis. Setting Nine University teaching Hospitals in Italy take part in this study in collaboration with the Department of Applied Science (DISBA) of the University of Basilicata. One hundred sixty-two patients, under elective cardiac and on pump surgery were enrolled in the study. From each patient 4 blood samples were collected during and at the end of the surgery, following the study design. Measurements and Main Results We observed, 30 minutes after the start of the surgery, lower gene expression levels of IL10 and PD1 in septic patients compared to non-septic (p<0.05), but considering all the timepoint there are differences in gene expression modulation between the groups. Conclusion These results confirmed the dysregulated immune response in septic patients compared to non-septic, highlight how a measurement of the gene expression could help to optimize procedures and pay attention to more susceptible patients. Incorrect table 1 (Table presented.) On pump surgery Age ≥ 18 years Exclusion criteria Emergency surgery Active endocarditis Previous sepsis or septic shock Unsigned informed consent Age < 18 years Correct table 1 (Table presented.) Elective cardiac surgery On pump surgery Age ≥18 years Emergency surgery Off pump surgery Active endocarditis Previous sepsis or septic shock Unsigned informed consent Age <18 years.