Transcriptional and functional effects of mavacamten in multiple porcine and human models with hypertrophic cardiomyopathy
These data suggest that MAVA not only inhibits force within the sarcomere but also influences transcriptional pathways in model-specific manner.
Authors
- Е. А. Киселев (ORCID: https://orcid.org/0000-0002-7179-8609)
- Wilhelm Korte
- Hannah Jill Hunkler (ORCID: https://orcid.org/0009-0008-3345-5585)
- Anika Gietz
- Evgeni G. Ponimaskin (ORCID: https://orcid.org/0000-0002-4570-5130)
- Oliver Beetz (ORCID: https://orcid.org/0000-0002-9213-5353)
- Thomas Thum (ORCID: https://orcid.org/0000-0003-4360-1511)
- Angelika Pfanne
- Shambhabi Chatterjee (ORCID: https://orcid.org/0000-0001-5978-3562)
- Jennifer M. Specht (ORCID: https://orcid.org/0000-0003-1484-2113)
- Ke Xiao (ORCID: https://orcid.org/0000-0002-6599-7118)
- Arjang Ruhparwar (ORCID: https://orcid.org/0000-0003-2725-9912)
- André Zeug (ORCID: https://orcid.org/0000-0001-9858-5841)
- Robert Zweigerdt (ORCID: https://orcid.org/0000-0002-4656-0770)
- Bettina Wiegmann (ORCID: https://orcid.org/0000-0001-6556-4059)
- Florian J. G. Waleczek (ORCID: https://orcid.org/0009-0006-9455-9412)
- Yiangos Psaras (ORCID: https://orcid.org/0000-0002-8697-6121)
- Marco Bentele
- Alexander Horke (ORCID: https://orcid.org/0000-0002-4578-1547)
- Elisa Mohr
- J. Salman (ORCID: https://orcid.org/0000-0002-7172-2946)
- Bjarne Jürgens
- Theresia Kraft (ORCID: https://orcid.org/0000-0002-8386-8088)
- Ante Radocaj (ORCID: https://orcid.org/0000-0003-4518-6323)
- Michael Pflaum (ORCID: https://orcid.org/0000-0002-4539-386X)
- Anselm A. Derda (ORCID: https://orcid.org/0000-0003-1968-189X)
- Christopher N. Toepfer (ORCID: https://orcid.org/0000-0003-4671-2030)
- Kristina Sonnenschein
- Kaja S. Menge (ORCID: https://orcid.org/0009-0004-2711-1621)
- Natalie Weber (ORCID: https://orcid.org/0000-0002-2302-1045)
- Christian Bär (ORCID: https://orcid.org/0000-0001-9276-9383)
- Maximilian Fuchs (ORCID: https://orcid.org/0000-0002-8099-9541)
- Giuseppe Cipriano (ORCID: https://orcid.org/0009-0000-7475-5367)
- Jonas A. Haas
- Susanne Neumüller
- Junqing Liu
- Wilson Agyapong
Institutions
- John Radcliffe Hospital (GB)
- Medizinische Hochschule Hannover (DE)
- University of Oxford (GB)
- Fraunhofer Institute for Toxicology and Experimental Medicine (DE)
- German Center for Lung Research (DE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1111/bph.70247
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- Medizinischen Hochschule Hannover