Transcriptional and functional effects of mavacamten in multiple porcine and human models with hypertrophic cardiomyopathy

These data suggest that MAVA not only inhibits force within the sarcomere but also influences transcriptional pathways in model-specific manner.

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Publication Details

Journal
British Journal of Pharmacology
Published
2025-11-10
DOI
https://doi.org/10.1111/bph.70247
Primary Topic
Cardiomyopathy and Myosin Studies
Type
article
Field-Weighted Citation Impact
0.00

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article

Transcriptional and functional effects of mavacamten in multiple porcine and human models with hypertrophic cardiomyopathy

Е. А. Киселев, Wilhelm Korte, Hannah Jill Hunkler, Anika Gietz et al.
British Journal of Pharmacology
Cardiomyopathy and Myosin Studies
article

Transcriptional and functional effects of mavacamten in multiple porcine and human models with hypertrophic cardiomyopathy

Е. А. Киселев, Wilhelm Korte, Hannah Jill Hunkler, Anika Gietz, Evgeni G. Ponimaskin, Oliver Beetz, Thomas Thum, Angelika Pfanne, Shambhabi Chatterjee, Jennifer M. Specht, Ke Xiao, Arjang Ruhparwar, André Zeug, Robert Zweigerdt, Bettina Wiegmann, Florian J. G. Waleczek, Yiangos Psaras, Marco Bentele, Alexander Horke, Elisa Mohr, J. Salman, Bjarne Jürgens, Theresia Kraft, Ante Radocaj, Michael Pflaum, Anselm A. Derda, Christopher N. Toepfer, Kristina Sonnenschein, Kaja S. Menge, Natalie Weber, Christian Bär, Maximilian Fuchs, Giuseppe Cipriano, Jonas A. Haas, Susanne Neumüller, Junqing Liu, Wilson Agyapong
article en

Abstract

These data suggest that MAVA not only inhibits force within the sarcomere but also influences transcriptional pathways in model-specific manner.

British Journal of PharmacologyVol. 183(5)
John Radcliffe Hospital (GB), Medizinische Hochschule Hannover (DE), University of Oxford (GB), Fraunhofer Institute for Toxicology and Experimental Medicine (DE), German Center for Lung Research (DE), RWTH Aachen University (DE)
Deutsche Forschungsgemeinschaft, Medizinischen Hochschule Hannover
Openalex Percentile: Top 49%
Cardiomyopathy and Myosin Studies
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