Development of micro-sequestra and associated histological changes in tooth extraction sockets of zoledronate-treated mice
This study demonstrated that there were micro-sequestra in tooth extraction sockets after zoledronic acid treatment, even if there was no osteonecrosis or bone exposure. Although the significance of bone fragments and the associated changes is unclear, these findings may assist in understanding the sub-clinical state of adverse effects induced by bisphosphonates.
Authors
- Gaku Koizumi
- Rina Yamada
- Kazuto Kurohara (ORCID: https://orcid.org/0000-0002-8859-7854)
- Kasumi Shimizu (ORCID: https://orcid.org/0000-0001-6498-9741)
- Akinobu Hayashi
- Taku Murata
- Naoya Arai
- Akira Takigawa
- Usagi Hayashi
Institutions
- Mie University (JP)
- Mie University Hospital (JP)
Publication Details
- Journal
- Journal of Oral Biosciences
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1016/j.job.2025.100710
- Primary Topic
- Bone health and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00