Gestational kynurenine metabolites mediate effects of pregnancy adiposity on child negative affect
This is the first evidence reporting that alterations in the kynurenine system during pregnancy are associated with increased child negative affectivity, an early life risk factor for psychopathology. Results further suggest that these kynurenine metabolites are a mechanistic link between pregnancy adiposity and child negative affect. Though observed effect sizes were small, results suggest that picolinic and quinolinic acid during pregnancy may be novel biomarkers for offspring behavioral risk.
Authors
- Hanna Gustafsson (ORCID: https://orcid.org/0000-0002-8258-4921)
- Harry W. Wright (ORCID: https://orcid.org/0009-0009-1900-163X)
- Joel T. Nigg (ORCID: https://orcid.org/0000-0003-0003-3024)
- Elinor L. Sullivan (ORCID: https://orcid.org/0000-0003-2630-8890)
- Jorden E. Jacinto Schreeder
Institutions
- Oregon Health & Science University (US)
Publication Details
- Journal
- Journal of Child Psychology and Psychiatry
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1111/jcpp.70071
- Citations
- 2
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- National Institutes of Health
- Oregon National Primate Research Center
- National Institute of Mental Health
- National Center for Advancing Translational Sciences