Validation of a Clinical and Polygenic Risk Prediction Model for Ovarian Cancer in the Nurses’ Health Study
In this study, we have validated the predictive performance of a combined clinical and polygenic model for ovarian cancer. Accurate risk assessment enables more efficient allocation of preventive interventions, including intensified surveillance and consideration of risk-reducing salpingo-oophorectomy among women at elevated risk.
Authors
- Erika L. Spaeth (ORCID: https://orcid.org/0000-0002-5397-3493)
- BERNARD A. ROSNER (ORCID: https://orcid.org/0000-0001-6907-0056)
- Gillian S. Dite (ORCID: https://orcid.org/0000-0002-2448-2548)
- Krishna Patel (ORCID: https://orcid.org/0009-0005-9246-3751)
Institutions
- Brigham and Women's Hospital (US)
- Heart Rhythm Society (US)
- AgriBio (AU)
Publication Details
- Journal
- Cancer Prevention Research
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1158/1940-6207.capr-24-0528
- Primary Topic
- Ovarian cancer diagnosis and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health