Successful Treatment of Severe Plaque Psoriasis in an Adolescent With a Combination of Methotrexate and Acitretin: A Case Report

Psoriasis is a chronic inflammatory skin disease that can occur at any age. It is a significant disease due to its appearance in visible areas, its potential to persist for years without treatment, and its association with various comorbidities. Severe psoriasis in children and young adolescents is particularly important because this period of life has a crucial impact on psychological development. The case presents a young adolescent with severe plaque psoriasis who was successfully treated with a combination of methotrexate and acitretin. This combination is not routinely used in daily practice due to concerns that it may cause serious hepatotoxicity.