Germline Variant Call Accuracy in Whole Genome Sequence Data from Canine Formalin-Fixed Paraffin-Embedded Tissue Samples

This pilot study demonstrates the feasibility of using FFPE samples from dogs for whole-genome sequencing and the detection of germline variants. Using FFPE samples in the analysis of suspected inherited diseases in domestic animals may represent a valuable approach in veterinary genetics if no other samples are available.

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Publication Details

Journal
Genes
Published
2025-11-11
DOI
https://doi.org/10.3390/genes16111371
Primary Topic
Human-Animal Interaction Studies
Type
article
Field-Weighted Citation Impact
0.00

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article

Germline Variant Call Accuracy in Whole Genome Sequence Data from Canine Formalin-Fixed Paraffin-Embedded Tissue Samples

Vidhya Jagannathan, Tosso Leeb
Genes
Human-Animal Interaction Studies
article

Germline Variant Call Accuracy in Whole Genome Sequence Data from Canine Formalin-Fixed Paraffin-Embedded Tissue Samples

Vidhya Jagannathan, Tosso Leeb
article en

Abstract

This pilot study demonstrates the feasibility of using FFPE samples from dogs for whole-genome sequencing and the detection of germline variants. Using FFPE samples in the analysis of suspected inherited diseases in domestic animals may represent a valuable approach in veterinary genetics if no other samples are available.

GenesVol. 16(11)
University of Bern (CH)
University of Bern
Openalex Percentile: Top 64%
Human-Animal Interaction Studies
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