PRC1-mediated H2A.Zub promotes gene expression by preventing H3.1K27me1 incorporation in Arabidopsis
Our findings reveal the long-sought mechanism by which PRC1 participates in transcriptional activation. We demonstrate that PRC1-mediated H2A.Zub, acting as a "switcher", plays a pivotal role in reprogramming active and repressed genes during the transition from embryonic to vegetative development. Moreover, our results provide new insights into the intricate relationship between histone modifications and histone variants in reprogramming and maintaining gene expression patterns.
Authors
- Javier Antúnez-Sánchez (ORCID: https://orcid.org/0000-0002-7485-7061)
- Myriam Calonje (ORCID: https://orcid.org/0000-0001-6351-6774)
- Jose Gutierrez‐Marcos (ORCID: https://orcid.org/0000-0002-5441-9080)
- Fernando Baile (ORCID: https://orcid.org/0000-0002-3923-0984)
Institutions
- University of Warwick (GB)
- Instituto de Bioquímica Vegetal y Fotosíntesis (ES)
Publication Details
- Journal
- Genome biology
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1186/s13059-025-03856-4
- Primary Topic
- Plant Molecular Biology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Biotechnology and Biological Sciences Research Council
- Agencia Estatal de Investigación