Low-valent cobalt catalyzed direct dehydroxylative cross-coupling of benzyl alcohols with aryl-chlorides
The direct functionalization of alcohols <i>via</i> C-O bond cleavage is a synthetically valuable but challenging transformation. In this work, we report a reductive C(sp<sup>3</sup>)-C(sp<sup>2</sup>) cross-coupling reaction between benzyl alcohols and a broad range of aryl chlorides. The success of this transformation is attributed to the development of low-coordinate cobalt/bipyridine complexes, which enable the selective conversion of benzyl alcohols into the corresponding diarylmethanes, while minimizing undesired homocoupling of either the benzyl alcohol or aryl chlorides.
Authors
- Valmik S. Shinde (ORCID: https://orcid.org/0000-0002-2185-9418)
- Magnus Rueping (ORCID: https://orcid.org/0000-0003-4580-5227)
- Prashant S. Shinde (ORCID: https://orcid.org/0000-0002-6804-7206)
Institutions
- Central Drug Research Institute (IN)
- King Abdullah University of Science and Technology (SA)
Publication Details
- Journal
- Chemical Science
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1039/d5sc05919d
- Citations
- 1
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- King Abdullah University of Science and Technology