More than half of shoulder vaccinations may end up in the subacromial space

Shoulder Injury Related to Vaccine Administration (SIRVA) can occur as subacromial bursitis, frozen shoulder, or tendinopathy following deltoid intramuscular immunization. This study evaluated needle overpenetration into the subacromial space using a standard needle in 177 patients undergoing arthroscopic shoulder surgery from 2022 to 2024, with a median age of 55. Findings showed a mean needle length of 25.36 mm was required for subacromial penetration, occurring in 51.9% of cases. Significant associations with needle overpenetration included Body Mass Index (BMI), weight, deltoid thickness, fat thickness, and combined fat and deltoid thickness, all statistically significant (p < 0.05). These results suggest the standard needle length may be too long for most adults, increasing complication risks. To prevent subacromial injections, the study recommends vaccination guidelines to adopt a shorter 15 mm needle for most adults, ensuring proper vaccine delivery into the deltoid muscle and minimizing SIRVA risk.

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Publication Details

Journal
npj Vaccines
Published
2025-11-11
DOI
https://doi.org/10.1038/s41541-025-01279-7
Primary Topic
Intramuscular injections and effects
Type
article
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article

More than half of shoulder vaccinations may end up in the subacromial space

Anthony L. Cunningham, Rodrigo Brandariz, Halah Kutaish, Grégory Cunningham et al.
npj Vaccines
Intramuscular injections and effects
article

More than half of shoulder vaccinations may end up in the subacromial space

Anthony L. Cunningham, Rodrigo Brandariz, Halah Kutaish, Grégory Cunningham, P. Bouché, Paolo Miguel Rivera, Shana Mombelli, Andres Rodriguez Borgonovo, Anne Cornevin, Benjamin De Pree
article en

Abstract

Shoulder Injury Related to Vaccine Administration (SIRVA) can occur as subacromial bursitis, frozen shoulder, or tendinopathy following deltoid intramuscular immunization. This study evaluated needle overpenetration into the subacromial space using a standard needle in 177 patients undergoing arthroscopic shoulder surgery from 2022 to 2024, with a median age of 55. Findings showed a mean needle length of 25.36 mm was required for subacromial penetration, occurring in 51.9% of cases. Significant associations with needle overpenetration included Body Mass Index (BMI), weight, deltoid thickness, fat thickness, and combined fat and deltoid thickness, all statistically significant (p < 0.05). These results suggest the standard needle length may be too long for most adults, increasing complication risks. To prevent subacromial injections, the study recommends vaccination guidelines to adopt a shorter 15 mm needle for most adults, ensuring proper vaccine delivery into the deltoid muscle and minimizing SIRVA risk.

npj VaccinesVol. 10(1)
University Hospital of Geneva (CH), Hirslanden Clinique La Colline (CH), James Lind Institute (CH), Westmead Institute (AU), Westmead Institute for Medical Research (AU), Geneva College (US)
Openalex Percentile: Top 51%
Intramuscular injections and effects
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More than half of shoulder vaccinations may end up in the subacromial space — Anthony L. Cunningham, Rodrigo Brandariz, et al. · npj Vaccines (2025) | TGRS Research Map | TGRS