Therapeutic Approaches for Enhancing Spinal Fusion in Low Back Pain: A Review With a Focus on the Elderly
Despite significant advancements, challenges such as optimizing biomaterial integration, mitigating inflammatory responses, and ensuring long-term stability remain. Future research should leverage precision medicine, artificial intelligence, and nanotechnology to enable patient-specific fusion strategies. A multidisciplinary approach will be essential to improve spinal fusion outcomes for aging populations.
Authors
- Shuimu Chen (ORCID: https://orcid.org/0009-0003-1820-380X)
- Christoph E. Albers (ORCID: https://orcid.org/0000-0003-2751-3458)
- Sebastian F. Bigdon (ORCID: https://orcid.org/0000-0002-4649-0610)
- Benjamin Gantenbein (ORCID: https://orcid.org/0000-0002-9005-0655)
- Sonja Häckel (ORCID: https://orcid.org/0000-0002-9415-6633)
- Zhen Li (ORCID: https://orcid.org/0000-0002-9754-6389)
Institutions
- University of Bern (CH)
- AO Foundation (CH)
- University Hospital of Bern (CH)
Publication Details
- Journal
- JOR Spine
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1002/jsp2.70136
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00