Single-cell multi-omics analysis reveals cellular subpopulations associated with relapse in high-risk B-ALL following intensified chemotherapy
Our study identified distinct cellular subpopulations associated with treatment failure, provide insights into the molecular mechanisms underlying treatment resistance in B-ALL and may inform the development of targeted therapies for high-risk patients.
Authors
- Li Liu (ORCID: https://orcid.org/0000-0003-0535-4361)
- Yan Zhou (ORCID: https://orcid.org/0000-0003-2661-4011)
- Yu Huang (ORCID: https://orcid.org/0000-0003-1500-0989)
- Chunhui Yang (ORCID: https://orcid.org/0000-0002-0649-5417)
- Shigang Yin (ORCID: https://orcid.org/0000-0003-0955-917X)
- Xin Tian (ORCID: https://orcid.org/0000-0001-9601-3751)
- Huangfan Xie (ORCID: https://orcid.org/0000-0002-6342-4316)
- Na Li (ORCID: https://orcid.org/0000-0002-0404-6431)
- Li Zhang (ORCID: https://orcid.org/0000-0003-1125-1991)
- Nanjing Jiang
- Xiaoyan Mao
Institutions
- Southwest Medical University (CN)
- Southern University of Science and Technology (CN)
- Affiliated Hospital of Southwest Medical University (CN)
- Chengdu Women's and Children's Central Hospital (CN)
- Kunming Children's Hospital (CN)
- Qujing Normal University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-12
- DOI
- https://doi.org/10.3389/fimmu.2025.1645546
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Southwest Medical University