Detection of spontaneous anti-neoepitope T-cell responses in non-metastatic bladder cancer patients
We show that one third of patients with non-metastatic bladder cancer mount a spontaneous and functional anti-neoepitope CD8<sup>+</sup> T-cell response detectable in blood or tumor. In 4 patients with NMIBC, BCG treatment did not boost or induce the anti-neoepitope response, suggesting alternative mechanisms of action for its efficacy.
Authors
- Hélène Dano (ORCID: https://orcid.org/0000-0001-5441-3714)
- Bertrand F. TOMBAL (ORCID: https://orcid.org/0000-0002-0093-8408)
- Beat Roth (ORCID: https://orcid.org/0000-0002-7369-650X)
- Alexandre Harari (ORCID: https://orcid.org/0000-0002-1055-2090)
- Audrey Masnada
- Raphaël Genolet (ORCID: https://orcid.org/0000-0001-9335-3945)
- Laurent Derré (ORCID: https://orcid.org/0000-0002-3403-161X)
- Denise Nardelli‐Haefliger (ORCID: https://orcid.org/0000-0003-1812-9905)
- Orian Bricard (ORCID: https://orcid.org/0000-0003-3976-7228)
- Nicolas van Baren (ORCID: https://orcid.org/0000-0003-4548-0266)
- Nicolas Dauguet (ORCID: https://orcid.org/0000-0002-4416-9903)
- Gérald Hames
- Walther Brochier (ORCID: https://orcid.org/0000-0002-1914-7673)
- Sonia-Cristina Rodrigues-Dias
- Sylvain Nguyen (ORCID: https://orcid.org/0000-0002-6508-1337)
- Pierre G. Coulie (ORCID: https://orcid.org/0000-0003-2916-2938)
- Valérie Cesson
- Ilaria Lucca (ORCID: https://orcid.org/0009-0000-4532-7961)
Institutions
- Cliniques Universitaires Saint-Luc (BE)
- University Hospital of Bern (CH)
- Ludwig Cancer Research (GB)
- de Duve Institute (BE)
- Ludwig Cancer Research (CH)
- University of Lausanne (CH)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-12
- DOI
- https://doi.org/10.3389/fimmu.2025.1627914
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Université de Lausanne
- Centre Hospitalier Universitaire Vaudois
- Walloon excellence in life sciences and biotechnology