Valid surrogate end-points in nonsmall cell lung cancer peri-operative systemic therapy trials: a systematic review
We identified 31 trials with a total of 15 776 patients. The weighted correlation coefficient was 0.86 based on the raw data from the 31 trials. After reciprocal duplication, the weighted correlation coefficient was 0.91 (p<0.001 for unweighted r). Subgroup analyses showed the correlation was 0.98 for trials with immune checkpoint inhibitors but was 0.54 for molecular targeted therapy CONCLUSIONS: We hope that our data will justify the use of the HRs of recurrence-, progression-, disease- and event-free survival as primary end-points in peri-operative immune checkpoint inhibitor regimens for NSCLC.
Authors
- Ayami Kaneko
- Hiroaki Fujii (ORCID: https://orcid.org/0000-0003-2336-0394)
- Katsushi Tanaka (ORCID: https://orcid.org/0000-0001-8543-2459)
- Ayako Aoki
- Yukihito Kajita
- Satoshi Nagaoka (ORCID: https://orcid.org/0009-0002-9786-8668)
- Nobuaki Kobayashi (ORCID: https://orcid.org/0000-0002-7064-320X)
- Kohei Somekawa
- Kota Murohashi (ORCID: https://orcid.org/0000-0002-2637-8218)
- Keisuke Watanabe (ORCID: https://orcid.org/0000-0001-9623-1492)
- Ryo Nagasawa
- Nobuyuki Horita (ORCID: https://orcid.org/0000-0002-8200-0340)
- Yu Hara (ORCID: https://orcid.org/0000-0002-2574-2516)
- Hiroyuki Adachi (ORCID: https://orcid.org/0000-0002-8928-9394)
- Ami Izawa (ORCID: https://orcid.org/0009-0006-7549-2734)
- Hiroyuki Yagyu (ORCID: https://orcid.org/0000-0003-4336-9919)
- Yohei Kameda (ORCID: https://orcid.org/0000-0002-4392-6319)
- Aya Saito (ORCID: https://orcid.org/0000-0001-6731-2007)
- Yukiko Otsu
- Rei Inoue (ORCID: https://orcid.org/0000-0001-6305-2519)
- Momo Hirata
- Suguru Muraoka
- Sousuke Kubo
- Takeshi Kaneko
Institutions
- Yokohama City University Hospital (JP)
- Equality Now (US)
- Yokohama City University (JP)
Publication Details
- Journal
- European Respiratory Review
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1183/16000617.0034-2025
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00