Phenotype, serotype, and data-driven clustering reveal complementary dimensions of heterogeneity in ANCA-associated vasculitis: a multicentre Japanese cohort (J-CANVAS)
Phenotype and serotype classifications provide complementary, not competing, prognostic insights in Japanese patients with AAV. Data-driven clustering revealed additional clinical heterogeneity not captured by traditional systems, underscoring the need for integrated, multi-dimensional stratification approaches to improve personalised risk assessment and treatment strategies.
Authors
- Naoho Takizawa (ORCID: https://orcid.org/0000-0003-3744-3537)
- Naoto Azuma (ORCID: https://orcid.org/0000-0002-4773-1535)
- Makoto Wada (ORCID: https://orcid.org/0000-0002-2183-5053)
- Ryo Nishioka (ORCID: https://orcid.org/0000-0001-8654-7311)
- Yutaka Kawahito (ORCID: https://orcid.org/0000-0002-3860-0488)
- Toshiko Ito‐Ihara (ORCID: https://orcid.org/0000-0001-7152-3026)
- Shoichi Fukui (ORCID: https://orcid.org/0000-0001-5487-4692)
- Kazuro Kamada
- Tomoaki Takata (ORCID: https://orcid.org/0000-0003-2959-6015)
- Hiroaki Dobashi (ORCID: https://orcid.org/0000-0003-2944-5583)
- Yasuhiro Shimojima (ORCID: https://orcid.org/0000-0001-7100-1121)
- Genki Kidoguchi (ORCID: https://orcid.org/0009-0001-0558-8814)
- Takashi Kawaguchi (ORCID: https://orcid.org/0000-0003-2446-7716)
- Tohru Takeuchi (ORCID: https://orcid.org/0000-0002-0065-929X)
- Takashi Kida (ORCID: https://orcid.org/0000-0002-5740-8352)
- Satoshi Ōmura (ORCID: https://orcid.org/0000-0002-9187-2044)
- Yuji Kukida (ORCID: https://orcid.org/0000-0003-4074-4533)
- Daiki Nakagomi (ORCID: https://orcid.org/0000-0003-1682-9799)
- Naoya Kondo (ORCID: https://orcid.org/0000-0002-8082-8849)
- Yoshia Miyawaki (ORCID: https://orcid.org/0000-0002-6981-3443)
- Toshihiko Takada (ORCID: https://orcid.org/0000-0002-8032-6224)
- Nobuyuki Yajima (ORCID: https://orcid.org/0000-0002-8292-3962)
- Tsuyoshi Shirai (ORCID: https://orcid.org/0000-0002-6295-3494)
- Isao Matsumoto (ORCID: https://orcid.org/0000-0002-7995-9294)
- Ryo Yanai (ORCID: https://orcid.org/0000-0003-3118-7675)
- Yusuke Yoshida (ORCID: https://orcid.org/0000-0002-0774-0509)
- Shintaro Hirata (ORCID: https://orcid.org/0000-0002-2474-9943)
- Yoshiyuki Abe (ORCID: https://orcid.org/0000-0002-1014-2868)
- Atsushi Nomura (ORCID: https://orcid.org/0000-0002-8194-6273)
- Takafumi Ito (ORCID: https://orcid.org/0000-0003-0677-6566)
- Ryota Okazaki
- Koji Endo
- H. Takagi
- Mayuko Moriyama
- Ayuko Takatani
- Yusuke Matsuo
Institutions
- Kanazawa University (JP)
- SHOWA Medical University (JP)
- Tokyo Medical and Dental University (JP)
- Fukushima Medical University (JP)
- Shinshu University (JP)
- University of Tsukuba (JP)
- Tokyo University of Pharmacy and Life Sciences (JP)
- Okayama University (JP)
- Shimane University (JP)
- Kagawa University (JP)
- Hokkaido University (JP)
- Juntendo University (JP)
- Kyoto Prefectural University of Medicine (JP)
- St. Luke's International Hospital (JP)
- Chubu Rosai Hospital (JP)
- Sasebo City General Hospital (JP)
- Tohoku University Hospital (JP)
- University of Yamanashi Hospital (JP)
- Kagoshima University Hospital (JP)
- Hiroshima University Hospital (JP)
- Kure Kyosai Hospital (JP)
- Tottori Prefectural Central Hospital (JP)
- University Hospital Kyoto Prefectural University of Medicine (JP)
- Teikyo University Chiba Medical Center (JP)
- Kyoto Katsura Hospital (JP)
- Japanese Red Cross Society Kyoto Daini Hospital (JP)
- Institute of Applied Biochemistry (JP)
- Nagasaki University (JP)
- Tottori University (JP)
- Hyogo University (JP)
- Osaka University of Pharmaceutical Sciences (JP)
Publication Details
- Journal
- Rheumatology International
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1007/s00296-025-06014-y
- Primary Topic
- Vasculitis and related conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.00