Fecal calprotectin and other biomarkers are not prospectively associated with food protein‐induced allergic proctocolitis
Concentrations of calprotectin, EDN, and zonulin were not associated with clinically diagnosed FPIAP in our cohort. Very high levels of calprotectin are noted in early infancy in asymptomatic healthy infants, and we provide normal ranges across the first year of life for all three biomarkers. This study does not support the use of fecal calprotectin, EDN, or zonulin for diagnosis of FPIAP.
Authors
- Moran Yassour (ORCID: https://orcid.org/0000-0002-7344-5188)
- Qian Yuan
- Katherine E. Gregory (ORCID: https://orcid.org/0000-0002-0610-5386)
- Victoria Martin (ORCID: https://orcid.org/0000-0002-4322-9564)
- José L. de Paz (ORCID: https://orcid.org/0000-0002-8555-2271)
- Yamini V. Virkud (ORCID: https://orcid.org/0000-0001-7328-7215)
- Wayne G. Shreffler (ORCID: https://orcid.org/0000-0001-6465-137X)
- M. E. Kirpas (ORCID: https://orcid.org/0000-0001-6027-7421)
- Timothy Sun (ORCID: https://orcid.org/0009-0001-0345-5700)
- Isabel O’Connell
Institutions
- University of North Carolina at Chapel Hill (US)
- Hebrew University of Jerusalem (IL)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- Journal of Pediatric Gastroenterology and Nutrition
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1002/jpn3.70257
- Citations
- 1
- Primary Topic
- Infant Nutrition and Health
- Type
- article
- Field-Weighted Citation Impact
- 1.12