MASE-GC: a multi-omics autoencoder and stacking ensemble framework for gastric cancer classification

MASE-GC advances computational oncology by offering an effective and generalizable framework for GC classification. By integrating multi-omics fusion, ensemble learning, and robust preprocessing, the proposed model improves both sensitivity and specificity, reduces false positives, and demonstrates strong potential for clinical translation in precision diagnostics and treatment planning.

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Publication Details

Journal
Frontiers in Cell and Developmental Biology
Published
2025-11-12
DOI
https://doi.org/10.3389/fcell.2025.1704237
Primary Topic
Ferroptosis and cancer prognosis
Type
article
Field-Weighted Citation Impact
0.00
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article

MASE-GC: a multi-omics autoencoder and stacking ensemble framework for gastric cancer classification

Ye Huang, Di Liu, Z.H. Che, Guannan Xu
Frontiers in Cell and Developmental Biology
Ferroptosis and cancer prognosis
article

MASE-GC: a multi-omics autoencoder and stacking ensemble framework for gastric cancer classification

Ye Huang, Di Liu, Z.H. Che, Guannan Xu
article en

Abstract

MASE-GC advances computational oncology by offering an effective and generalizable framework for GC classification. By integrating multi-omics fusion, ensemble learning, and robust preprocessing, the proposed model improves both sensitivity and specificity, reduces false positives, and demonstrates strong potential for clinical translation in precision diagnostics and treatment planning.

Frontiers in Cell and Developmental BiologyVol. 13
Jinzhou Medical University (CN)
Openalex Percentile: Top 51%
Ferroptosis and cancer prognosis
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