Potential Benefits of Nigella Sativa (Black Seeds) in the Management of Coronavirus Disease-2019 (COVID-19)-Associated New-Onset Diabetes Mellitus (NODM): An Overview

After recovering from COVID-19, several patients experienced beta-cell dysfunction, insulin resistance, pancreatic dysfunction, reduced insulin production, and New Onset Diabetes Mellitus (NODM). The purpose of this review was to examine the potential advantages of black seeds (Nigella sativa or N. sativa) in the treatment of post-COVID NODM. With a focus on pertinent publications, the literature search was carried out utilizing electronic databases such as Medline, PubMed, PMC, Scopus, Web of Science, Science Direct, Google Scholar, and reference lists. Numerous RCTs, systematic reviews, and meta-analyses have established N. sativa's antidiabetic potential as well as its other pleiotropic effects, such as its anti-inflammatory, antioxidant, and anti-COVID properties. Through a variety of possible mechanisms, N. sativa may reduce glycated Hemoglobin (HbA1c), Postprandial Blood Glucose (PPBG), Fasting Blood Glucose (FBG), and other indices. The long-term effects of N. sativa in the treatment of COVID-associated NODM should be investigated in future studies.