Cover Feature: <i>β</i> ‐Amino Acid Synthesis Using the CO <sub>2</sub> Radical Anion under Electrochemical and Photochemical Conditions (ChemistryEurope 6/2025)
The Cover Feature shows how the reaction path of CO2 radical anion addition to N-Ac-enamide was explored by using automated reaction path search methods. Analysis revealed that β-position addition is both kinetically and thermodynamically favored over α-position addition, leading to the selective formation of β-amino acids. This computational prediction was further supported by experimental validation. More information can be found in the Research Article by S. Maeda, T. Mita and co-workers (DOI: 10.1002/ceur.202500184).
Authors
- Tsuyoshi Mita (ORCID: https://orcid.org/0000-0002-6655-3439)
- Satoshi Maeda (ORCID: https://orcid.org/0000-0001-8822-1147)
- Kosaku Tanaka (ORCID: https://orcid.org/0000-0002-3591-5409)
- Wataru Kanna (ORCID: https://orcid.org/0000-0002-2931-6661)
- Yamato Ueno (ORCID: https://orcid.org/0009-0008-4494-5344)
- Tavinder Singh (ORCID: https://orcid.org/0009-0009-6634-6948)
- Yu Harabuchi (ORCID: https://orcid.org/0000-0001-8313-3236)
Institutions
- Hokkaido University (JP)
Publication Details
- Journal
- ChemistryEurope
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1002/ceur.70141
- Primary Topic
- Metalloenzymes and iron-sulfur proteins
- Type
- article
- Field-Weighted Citation Impact
- 0.00